MAPROTILENE HYDROCHLORIDE
maprotiline hydrochloride
CAS: 10347-81-6
Molecular Formula: C20H24ClN
MAPROTILENE HYDROCHLORIDE - Names and Identifiers
| Name | maprotiline hydrochloride |
| Synonyms | ba34276 ciba34276ba Maprotiline HCL ciba34276hydrochloride maprotiline hydrochloride MAPROTILENE HYDROCHLORIDE 10-ethanoanthracene-9(10h)-propylamine,n-methyl-hydrochloride n-methyl-9,10-ethanoanthracene-9(10h)-propanaminehydrochloride 1-(3-METHYLAMINOPROPYL)DIBENZO[B,E]BICYCLO[2.2.2]OCTADIENE HYDROCHLORIDE 9-[GAMMA-METHYLAMINOPROPYL]-9,10-DIHYDRO-9,10-ETHANOANTHRACENE HYDROCHLORIDE |
| CAS | 10347-81-6 |
| EINECS | 233-758-8 |
| InChI | InChI=1/C20H23N.ClH/c1-21-14-6-12-20-13-11-15(16-7-2-4-9-18(16)20)17-8-3-5-10-19(17)20;/h2-5,7-10,15,21H,6,11-14H2,1H3;1H/t15-,20+ |
MAPROTILENE HYDROCHLORIDE - Physico-chemical Properties
| Molecular Formula | C20H24ClN |
| Molar Mass | 313.86 |
| Melting Point | 230-232°C |
| Boling Point | 428.2°C at 760 mmHg |
| Flash Point | 9℃ |
| Water Solubility | Soluble to 50mg/ml in water. Soluble in ethanol at 10mM |
| Solubility | H2O: 50mg/mL |
| Vapor Presure | 9.8E-08mmHg at 25°C |
| Appearance | powder |
| Color | white |
| Merck | 14,5748 |
| Storage Condition | 2-8°C |
| Use | Antidepressants for various types of depressive neurosis such as endogenous, reactive, menopause |
MAPROTILENE HYDROCHLORIDE - Risk and Safety
| Risk Codes | R22 - Harmful if swallowed R39/23/24/25 - R23/24/25 - Toxic by inhalation, in contact with skin and if swallowed. R11 - Highly Flammable |
| Safety Description | S7 - Keep container tightly closed. S16 - Keep away from sources of ignition. S36/37 - Wear suitable protective clothing and gloves. S45 - In case of accident or if you feel unwell, seek medical advice immediately (show the label whenever possible.) |
| UN IDs | 3249 |
| WGK Germany | 3 |
| RTECS | KJ4555000 |
| HS Code | 2921490002 |
| Hazard Class | 6.1(b) |
| Packing Group | III |
| Toxicity | LD50 in mice, rats (mg/kg): ~750, ~900 orally (Hess) |
MAPROTILENE HYDROCHLORIDE - Standard
Authoritative Data Verified Data
This product is N-methyl -9, 10-bridged ethylene-9 (10h)-propylamine hydrochloride. The content of C20H23N • HCl shall not be less than 99.0% calculated on a dry basis.
Last Update：2024-01-02 23:10:35
MAPROTILENE HYDROCHLORIDE - Trait
Authoritative Data Verified Data
- This product is white or off-white crystalline powder; Odorless.
- This product is soluble in methanol or chloroform, slightly soluble in water, insoluble in n-heptane.
Last Update：2022-01-01 14:20:36
MAPROTILENE HYDROCHLORIDE - Differential diagnosis
Authoritative Data Verified Data
- take about 5mg of this product, add 5ml of water to dissolve, and add several drops of bismuth potassium iodide solution to generate orange yellow precipitate.
- take this product, add water to dissolve and dilute to make about 0. The 1 mg solution, as determined by UV-Vis spectrophotometry (General 0401), has an absorption maximum at wavelengths of NM and Nm.
- The infrared absorption spectrum of this product should be consistent with that of the control (Spectrum set 634).
- This product is chloride identification reaction (General 0301).
Last Update：2022-01-01 14:20:37
MAPROTILENE HYDROCHLORIDE - Exam
Authoritative Data Verified Data
clarity and color of solution
take this product l. After being dissolved by adding 20ml of methanol, the solution shall be clear and colorless; In case of color development, it shall not be deeper in comparison with yellow or yellow-green No. 2 Standard Colorimetric solution (General rule 0901 first method).
Related substances
take this product, add methanol to dissolve and dilute to make a solution containing about 20mg per lml, as a test solution; Take appropriate amount of precision, diluted with methanol to make about 0.2mg, 0. Solutions of 1 mg and 0.05mg were used as control solutions (1), (2) and (3). According to the thin layer chromatography (General 0502) test, absorb the above four solutions of 15 u1, respectively, in the same silica gel G thin layer plate (pre-developed with chloroform, and dried at 100 C for 30 minutes) on, with isobutyl-acetic acid-acetic acid -2mol/L ammonium hydroxide solution (6:3:1) as the developer (the bottom of the chromatography cylinder put a 4ml small beaker containing concentrated ammonia solution, add the developer and pre-equilibrate for 1 hour), spread out, dry, the thin plate in concentrated hydrochloric acid steam for 30 minutes, take out, put under UV lamp (254nm) irradiation for 10 minutes, in UV lamp (365mn) next view. Test solution such as impurity spots, not more than 2, its color and control solution (1), (2) and (3) show the main spot, the total amount of impurities should not exceed 1.0%.
loss on drying
take this product, dry to constant weight at 105°C, weight loss shall not exceed 1.0% (General rule 0831).
ignition residue
take l.Og of this product and check it according to law (General rule 0841). The residue left shall not exceed 0.1%.
Heavy metals
The residue left under the item of taking the ignition residue shall not contain more than 10 parts per million of heavy metal when examined by law (General Principles 0821, Law II).
Last Update：2022-01-01 14:20:38
MAPROTILENE HYDROCHLORIDE - Content determination
Authoritative Data Verified Data
take about 0.25g of this product, precision weighing, add 25ml of glacial acetic acid and 5ml of Mercury acetate test solution, add 1 drop of crystal violet indicator solution, and use perchloric acid titration solution (O. 1 mol/L) titration to a blue color of the solution, and the results of the titration were corrected by a blank test. Each 1 ml perchloric acid titration solution (0.1 mol/L) corresponds to 31.39mg of c20 h23n-HCL.
Last Update：2022-01-01 14:20:38
MAPROTILENE HYDROCHLORIDE - Category
Authoritative Data Verified Data
antidepressants.
Last Update：2022-01-01 14:20:38
MAPROTILENE HYDROCHLORIDE - Storage
Authoritative Data Verified Data
sealed storage.
Last Update：2022-01-01 14:20:39
MAPROTILENE HYDROCHLORIDE - Maprotiline Hydrochloride Tablets
Authoritative Data Verified Data
This product contains maprotiline hydrochloride (C20H23N • HCl) should be 90.0% ~ 110.0% of the label amount.
trait
This product is white or white-like tablets or film-coated tablets, white or white-like after removing the coating.
identification
- take an appropriate amount of fine powder of this product, add an appropriate amount of water, shake to dissolve maprotiline hydrochloride, filter, take the filtrate according to the identification under maprotiline hydrochloride (1), (2) the same results were seen in one trial.
- in the chromatogram recorded under the content determination item, the retention time of the main peak of the test solution should be consistent with the retention time of the main peak of the reference solution.
examination
-
The content uniformity of
- shall be calculated from the content of each tablet measured under the content determination item, and shall comply with the regulations (General rule 0941).
- the dissolution of this product 1 tablet, according to the dissolution and release determination method (General rule 0931 The first method), with hydrochloric acid solution (9-) 500ml as the dissolution medium, at 100 rpm, operate according to law. After 20 minutes, filter the solution and take the filtrate as the test solution, the dissolution medium was added to dissolve and quantitatively dilute to prepare a solution containing about 50ug per 1 ml as a reference solution. The sample solution and the reference solution were respectively 10UL, and the dissolution amount of each tablet was calculated according to the method under the content determination item. The limit is 75% of the labeled amount and shall be in accordance with the provisions.
- others shall be in accordance with the relevant provisions under the item of tablets (General rule 0101).
Content determination
- measured by high performance liquid chromatography (General 0512).
- chromatographic conditions and system suitability test using eighteen alkyl silane bonded silica gel as filler; Ammonium sulfate buffer (take ammonium sulfate 10.5g and triethylamine 2ml, add water 1000ml to dissolve, adjust pH value to 4.0 with dilute sulfuric acid)-Methanol (40: 60) as mobile phase; The detection wavelength was 230nm; The column temperature was 35 ° C.; The number of theoretical plates was not less than 3000 calculated by maprotiline peak.
- determination Method: Take 10 tablets of this product, put them in 50ml measuring flask respectively, add appropriate amount of mobile phase, sonicate for 10 minutes and fully shake to dissolve maprotiline hydrochloride, and let them cool, dilute to the scale with mobile phase, shake, filter, take the filtrate as the test solution, take 10u1 injection of human liquid chromatography with precision, record the chromatogram; Take maprotiline hydrochloride control, precision weighing, and mobile phase dissolution and quantitative dilution made of each 1 ml containing about 0.5mg of the solution, the same method. According to the external standard method, the content of each tablet is calculated by Peak area, and the average content is obtained.
category
Same as maprotiline hydrochloride.
specification
25mg
storage
sealed storage.
Last Update：2022-01-01 14:20:39
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Mobile: 609-228-6898
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View History
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